Sharath Hegde

Company: Congruence Therapeutics

Job title: Chief Scientific Officer

Seminars:

Discovery of Small Molecule Melanocortin MC4R Correctors to Treat Early-Onset Obesity in MC4R Deficient Patients 11:40 am

Loss-of-function mutations in the MC4R gene, resulting in impaired trafficking of MC4R to the plasma membrane, leads to MC4R deficiency (MC4R-d) in the paraventricular nucleus of the hypothalamus MC4R-d causes severe hyperphagia and is the leading monogenic cause of obesity Small molecule pharmacological correctors that stabilize and chaperone MC4R to the cell-surface to restore their…Read more

day: Day Two