Marco Tozzi

Company: Gubra

Job title: Senior Scientist

Seminars:

A Humanized GLP-1 Receptor Mouse Model for Translational Drug Development 11:55 am

Species-specific activation of the GLP-1 receptor by small-molecule agonists poses challenges for preclinical efficacy testing We engineered and validated a knock-in mouse model expressing the human GLP-1 receptor to support translational drug discovery Both semaglutide and orforglipron elicited hallmark metabolic effects in hGLP1R mice, while only semaglutide was effective in wild-type controls Brain activation patterns…Read more

day: Day Two