Ansarullah .
Associate Director - Metabolic Phenotyping The Jackson Laboratory
Seminars
Thursday 16th July 2026
Survodutide Responses Across Diet-Induced, Polygenic, and Outbred Mouse Models
12:00 pm
- Survodutide robustly reduced body weight and fat mass in DIO mice by significantly enhancing energy expenditure, but was accompanied by lean mass loss not seen in other models
- Polygenic NZO/HILtJ and Diversity Outbred mice showed effective fat mass reduction and lean mass preservation without increased energy expenditure, demonstrating that this effect is model-dependent rather than a universal GLP-1/GCGR pharmacological effect
- Diversity Outbred mice revealed striking inter-individual variability in survodutide response, highlighting the power of genetically diverse preclinical platforms for advancing precision medicine in obesity and metabolic disease
