Underneath the Lost Kilos: Body Composition Imaging & Beyond During Weight Loss
- Assessing Body composition: different measurement methodologies (DXA, CT, MRI) assess body composition differently and will meet different needs in clinical trials
- Muscle volumes, fat, & function: individually segmenting muscles enables us to measure different types of muscle fat, monitor changes reliably over time, and integrate imaging with different muscle function assessments
- Health effects beyond body composition: weight loss can have direct and indirect benefits in a number of end organs (e.g. liver, kidney) and downstream conditions (e.g. HFpEF), which can be captured in clinical trials with shorter durations and smaller patient populations using imaging