Increasing Thermogenic Adipocytes to Treat Obesity & Cardiometabolic Diseases
- All currently approved obesity drugs act by reducing food intake, causing a drop in metabolic rate (thermogenesis) • To achieve durable weight control and cardiometabolic benefits, agents that increase metabolic rate are needed to complement existing therapies
- Energesis Pharmaceuticals is developing oral small molecules and proteins that boost energy expenditure – the missing therapeutic dimension in obesity treatment
- Energesis uses a proprietary platform of human brown/beige/brite adipocyte adult stem cells to discover novel targets and develop therapies that increase the amount of brown fat and induce long-term weight loss
- Our drug candidates drive robust fat-specific weight loss – without muscle loss – and show strong synergy with GLP-1 agents