A Humanized GLP-1 Receptor Mouse Model for Translational Drug Development
Time: 11:55 am
day: Day Two
Details:
- Species-specific activation of the GLP-1 receptor by small-molecule agonists poses challenges for preclinical efficacy testing
- We engineered and validated a knock-in mouse model expressing the human GLP-1 receptor to support translational drug discovery
- Both semaglutide and orforglipron elicited hallmark metabolic effects in hGLP1R mice, while only semaglutide was effective in wild-type controls
- Brain activation patterns induced by both agonists showed substantial overlap
